derivatives had any therapeutic value of their own.

Piperidine, the decomposition product of piperine, which we have shown
may be considered to be hexahydropyridine, was examined by Dr.
Kronecker, of Berlin, at the request of Prof. Hofmann, and was found to
have an action upon animals in many respects resembling that of conine.
Prof. Filehne, of Erlangen, who has studied a large number of these
pyridine and quinoline derivatives, found, moreover, that the
hydrochlorate of ethyl-piperidine had a physiological action quite
analogous to that of conine.

The physiological action of quinoline itself has been studied quite
extensively by Donath and others, and it was found that several of its
salts were quite valuable febrifuges, acting very like quinine, and
capable in cases of being used as a substitute for it. In general, the
hydrogen addition products were found to be more active than the simple
base, an observation entirely in accord with the theory formed by
Wischnegradsky, and by Konigs, as the result of the study of the
decomposition products of the alkaloids, viz., the alkaloids are in
general hydrogen addition products of pyridine and quinoline, or of the
two bases combined. Thus Prof. Filehne found that hydrochlorate of
tetrahydroquinoline was much more energetic in its action than
quinoline, but could not be used on account of a too powerful local
effect. The hydrochlorate of dimethyl-tetrahydroquinoline, which was
distinguished by its strong bitter taste, much resembling that of
quinine, had an effect like that of curare poison. The most decided
febrifuge action, however was found by Prof. Filehne to reside in the
hydrochlorate of oxyhydro-methyl-quinoline, introduced to public notice
by Prof. O. Fischer under the name of "Kairin," and in the acid sulphate
of tetrahydro-methylquinoline, introduced under the name of "Kairolin."