is met with almost exclusively between the knee and the ankle, and it
usually affects both legs. It is commonest in girls of delicate
constitution, in whose family history there is evidence of a tuberculous
taint. The patient often presents other lesions of a tuberculous
character, notably enlarged cervical glands, and phlyctenular
ophthalmia. The tubercle bacillus has rarely been found, but we have
always observed characteristic epithelioid cells and giant cells in
sections made from the edge or floor of the ulcer.

[Illustration: FIG. 16.--Bazin's Disease in a girl æt. 16.]

The condition begins by the formation in the skin and subcutaneous
tissue of dusky or livid nodules of induration, which soften and
ulcerate, forming small open sores with ragged and undermined edges, not
unlike those resulting from the breaking down of superficial syphilitic
gummata (Fig. 16). Fresh crops of nodules appear in the neighbourhood of
the ulcers, and in turn break down. While in the nodular stage the
affection is sometimes painful, but with the formation of the ulcer the
pain subsides.

The disease runs a chronic course, and may slowly extend over a wide
area in spite of the usual methods of treatment. After lasting for some
months, or even years, however, it may eventually undergo spontaneous
cure. The most satisfactory treatment is to excise the affected tissues
and fill the gap with skin-grafts.

[Illustration: FIG. 17.--Syphilitic Ulcers in region of Knee, showing
punched-out appearance and raised indurated edges.]

The _syphilitic ulcer_ is usually formed by the breaking down of a