culture. Just at this time, however, the catamenial function began to
show signs of failure of power. No severe or even moderate illness
overtook her. She was subjected to no unusual strain. She was only
following the regimen of continued and sustained work, regardless of
Nature's periodical demands for a portion of her time and force, when,
without any apparent cause, the failure of power was manifested by
moderate dysmenorrhoea and diminished excretion. Soon after this the
function ceased altogether; and up to this present writing, a period
of six or eight years, it has shown no more signs of activity than an
amputated arm. In the course of a year or so after the cessation of
the function, her head began to trouble her. First there was headache,
then a frequent congested condition, which she described as a "rush
of blood" to her head; and, by and by, vagaries and forebodings and
despondent feelings began to crop out. Coincident with this mental
state, her skin became rough and coarse, and an inveterate acne
covered her face. She retained her appetite, ability to exercise and
sleep. A careful local examination of the pelvic organs, by an expert,
disclosed no lesion or displacement there, no ovaritis or other
inflammation. Appropriate treatment faithfully persevered in was
unsuccessful in recovering the lost function. I was finally obliged to
consign her to an asylum.

The arrest of development of the reproductive system is most obvious
to the superficial observer in that part of it which the milliner is
called upon to cover up with pads, and which was alluded to in the
case of Miss D----. This, however, is too important a matter to be
dismissed with a bare allusion. A recent writer has pointed out the
fact and its significance with great clearness. "There is another
marked change," says Dr. Nathan Allen, "going on in the female
organization at the present day, which is very significant of