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Medical Essays, 1842-1882 by Oliver Wendell Holmes
page 52 of 423 (12%)
which has had the polish removed from the lower part of its cavity by
rubbing it with wet sand; they are to be mingled for an instant with a
bone or horn spatula, and then rubbed together for six minutes; then the
mass is to be scraped together from the mortar and pestle, which is to
take four minutes; then to be again rubbed for six minutes. Four minutes
are then to be devoted to scraping the powder into a heap, and the second
third of the hundred grains of sugar of milk to be added. Then they are
to be stirred an instant and rubbed six minutes,--again to be scraped
together four minutes and forcibly rubbed six; once more scraped together
for four minutes, when the last third of the hundred grains of sugar of
milk is to be added and mingled by stirring with the spatula; six minutes
of forcible rubbing, four of scraping together, and six more (positively
the last six) of rubbing, finish this part of the process.

Every grain of this powder contains the hundredth of a grain of the
medicinal substance mingled with the sugar of milk. If, therefore, a
grain of the powder just prepared is mingled with another hundred grains
of sugar of milk, and the process just described repeated, we shall have
a powder of which every grain contains the hundredth of the hundredth, or
the ten thousandth part of a grain of the medicinal substance. Repeat
the same process with the same quantity of fresh sugar of milk, and every
grain of your powder will contain the millionth of a grain of the
medicinal substance. When the powder is of this strength, it is ready to
employ in the further solutions and dilutions to be made use of in
practice.

A grain of the powder is to be taken, a hundred drops of alcohol are to
be poured on it, the vial is to be slowly turned for a few minutes, until
the powder is dissolved, and two shakes are to be given to it. On this
point I will quote Hahnemann's own words. "A long experience and
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