In Florence, despite all that human wisdom and forethought could devise to
avert it, as the cleansing of the city from many impurities by officials
appointed for the purpose, the refusal of entrance to all sick folk, and the
adoption of many precautions for the preservation of health; despite also
humble supplications addressed to God, and often repeated both in public
procession and otherwise, by the devout; towards the beginning of the spring
of the said year the doleful effects of the pestilence began to be horribly
apparent by symptoms that shewed as if miraculous.

Not such were they as in the East, where an issue of blood from the nose was
a manifest sign of inevitable death; but in men and women alike it first
betrayed itself by the emergence of certain tumours in the groin or the
armpits, some of which grew as large as a common apple, others as an egg,
some more, some less, which the common folk called gavoccioli. From the two
said parts of the body this deadly gavocciolo soon began to propagate and
spread itself in all directions indifferently; after which the form of the
malady began to change, black spots or livid making their appearance in many
cases on the arm or the thigh or elsewhere, now few and large, now minute
and numerous. And as the gavocciolo had been and still was an infallible
token of approaching death, such also were these spots on whomsoever they
shewed themselves. Which maladies seemed to set entirely at naught both the
art of the physician and the virtues of physic; indeed, whether it was that
the disorder was of a nature to defy such treatment, or that the physicians
were at fault--besides the qualified there was now a multitude both of men
and of women who practised without having received the slightest tincture of
medical science--and, being in ignorance of its source, failed to apply the
proper remedies; in either case, not merely were those that recovered few,
but almost all within three days from the appearance of the said symptoms,
sooner or later, died, and in most cases without any fever or other