Dying childless, he was succeeded by his brother John, whose two sons,
Henry and William, of Nassau, divided the great inheritance after their
father's death, William succeeded to the German estates, became a convert
to Protestantism, and introduced the Reformation into his dominions.
Henry, the eldest son, received the family possessions and titles in
Luxembourg, Brabant, Flanders and Holland, and distinguished himself as
much as his uncle Engelbert, in the service of the Burgundo-Austrian
house. The confidential friend of Charles the Fifth, whose governor he
had been in that Emperor's boyhood, he was ever his most efficient and
reliable adherent. It was he whose influence placed the imperial crown
upon the head of Charles. In 1515 he espoused Claudia de Chalons, sister
of Prince Philibert of Orange, "in order," as he wrote to his father,
"to be obedient to his imperial Majesty, to please the King of France,
and more particularly for the sake of his own honor and profit."

His son Rene de Nassau-Chalons succeeded Philibert. The little
principality of Orange, so pleasantly situated between Provence and
Dauphiny, but in such dangerous proximity to the seat of the "Babylonian
captivity" of the popes at Avignon, thus passed to the family of Nassau.
The title was of high antiquity. Already in the reign of Charlemagne,
Guillaume au Court-Nez, or "William with the Short Nose," had defended
the little--town of Orange against the assaults of the Saracens. The
interest and authority acquired in the demesnes thus preserved by his
valor became extensive, and in process of time hereditary in his race.
The principality became an absolute and free sovereignty, and had already
descended, in defiance of the Salic law, through the three distinct
families of Orange, Baux, and Chalons.

In 1544, Prince Rene died at the Emperor's feet in the trenches of Saint
Dizier. Having no legitimate children, he left all his titles and