express with much confidence settled opinions upon the subject. My
object will be fully attained if I succeed in giving a just and
truthful impression of the more marked final consequences of the hasty
disuse of opium in this single case, leaving it to medical men to
explain the complicated relations of an opium-saturated constitution
to the free and healthy functions of life.

In my own case, the most marked among the later consequences of the
disease of opium, some of which remain to the present time and seem to
be permanently engrafted upon the constitution, have been these:

1. Pressure upon the muscles of the limbs and in the extremities,
sometimes as of electricity apparently accumulated there under a
strong mechanical force.

2. A disordered condition of the liver, exhibiting itself in the
variety of uncomfortable modes in which that organ, when acting
irregularly, is accustomed to assert its grievances.

3. A sensitive condition of the stomach, rejecting many kinds of food
which are regarded by medical men as simple and easy of digestion.

4. Acute shooting pains, confined to no one part of the body.

5. An unnatural sensitiveness to cold.

6. Frequent cold perspiration in parts of the body.

7. A tendency to impatience and irritability of temper, with paroxysms
of excitement wholly foreign to the natural disposition.